Aconitate Delta-isomerase

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Aconitate Δ-isomerase
Aconitate Δ-isomerase
Identifiers
EC no.	5.3.3.7
CAS no.	37318-48-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
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PMC	articles
PubMed	articles
NCBI	proteins

In enzymology, an aconitate Δ-isomerase (EC 5.3.3.7) is an enzyme that catalyzes the chemical reaction

trans-aconitate

\rightleftharpoons

cis-aconitate

Hence, this enzyme has one substrate, trans-aconitate, and one product, cis-aconitate.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is aconitate Delta2-Delta3-isomerase. This enzyme is also called aconitate isomerase.

References[edit]

Klinman JP; Rose IA (1971). "Purification and kinetic properties of aconitate isomerase from Pseudomonas putida". Biochemistry. 10 (12): 2253–2259. doi:10.1021/bi00788a011. PMID 5114987.
Klinman JP, Rose IA (1971). "Mechanism of the aconitate isomerase reaction". Biochemistry. 10 (12): 2259–66. doi:10.1021/bi00788a012. PMID 5114988.

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v t e Isomerases: intramolecular oxidoreductases (EC 5.3)
5.3.1: Aldoses/Ketoses	Triosephosphate isomerase Ribose-5-phosphate isomerase Mannose phosphate isomerase Glucose isomerase
5.3.2: Keto/Enol	Phenylpyruvate tautomerase Oxaloacetate tautomerase 4-Oxalocrotonate tautomerase
5.3.3: C = C	Steroid D-isomerase Isopentenyl-diphosphate delta isomerase Vinylacetyl-CoA D-isomerase Muconolactone D-isomerase Cholestenol Delta-isomerase (EBP) Methylitaconate D-isomerase Aconitate Delta-isomerase Enoyl CoA isomerase Prostaglandin-A1 Delta-isomerase 5-carboxymethyl-2-hydroxymuconate D-isomerase Isopiperitenone D-isomerase L-dopachrome isomerase Polyenoic fatty acid isomerase
5.3.4: S-S	Protein disulfide-isomerase (PDIA3)
5.3.99: other	Prostaglandin D2 synthase/Prostaglandin-D synthase Prostaglandin E synthase Prostacyclin synthase Thromboxane-A synthase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)