CRTC1

CRTC1
Идентификаторы
Псевдонимы	CRTC1 , MECT1, TORC-1, TORC1, WAMTP1, CREB регулируемый транскрипционным коактиватором 1, MAML2, MAM-2
Внешние идентификаторы	Омим : 607536 ; MGI : 2142523 ; Гомологен : 41607 ; GeneCards : CRTC1 ; OMA : CRTC1 - ортологи
показывать Местоположение гена ( человек )
Chr.	Chromosome 19 (human)
End	18,782,333 bp
показывать Местоположение гена ( мышь )
Chr.	Chromosome 8 (mouse)
End	70,892,229 bp
показывать РНК -паттерн экспрессии
	Top expressed in
	beta cell; ; paraflocculus of cerebellum; ; right hemisphere of cerebellum; ; Brodmann area 10; ; middle frontal gyrus; ; frontal pole; ; cerebellar vermis; ; right frontal lobe; ; nucleus accumbens; ; cingulate gyrus;
	Top expressed in
	superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; genital tubercle; ; lumbar subsegment of spinal cord; ; tail of embryo; ; neural layer of retina; ; cerebellar cortex; ; hippocampus proper; ; zygote;
	More reference expression data
	More reference expression data
показывать Джин Онтология
Molecular function	protein binding; cAMP response element binding protein binding;
Cellular component	neuronal cell body; plasma membrane; dendrite; synapse; nucleus; nucleoplasm; cytoplasm; cytosol; nuclear body; postsynaptic density; glutamatergic synapse;
Biological process	positive regulation of CREB transcription factor activity; viral process; positive regulation of dendrite development; memory; entrainment of circadian clock by photoperiod; protein homotetramerization; positive regulation of long-term synaptic potentiation; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; rhythmic process; regulation of transcription, DNA-templated; energy homeostasis; negative regulation of membrane hyperpolarization; postsynapse to nucleus signaling pathway;
	Sources:Amigo / QuickGO
скрывать Ортологи
	23373
	382056
	ENSG00000105662
	EMSMUSM000000035755
	Q6UUV9
	Q68ED7
	NM_001098482; NM_015321; NM_025021
	NM_001004062
	NP_001091952; NP_056136
showNP_001004062; NP_001391344; NP_001391345; NP_001391346; NP_001391347;
	NP_001391348; NP_001391349; NP_001391350; NP_001391351; NP_001391352; NP_001391353; NP_001391354; NP_001391355; NP_001391356; NP_001391357; NP_001391358; NP_001391359
	Wikidata
View/Edit Human	View/Edit Mouse

CREB-регулируемый транскрипционным коактиватором 1 (CRTC1) ранее называемый TORC1 ( T RANSDUCER E - FRELED , C REB ACTIOL 1 ), является белком , который у людей кодируется CRTC1 геном . ^{[ 5 ]}^{[ 6 ]}^{[ 7 ]}^{[ 8 ]} Он экспрессируется в ограниченном количестве тканей, которые включают в себя мозг плода и сердце и взрослые, скелетные мышцы, печень и слюнные железы ^{[ 9 ]} и различные области центральной нервной системы взрослых. ^{[ 10 ]}

Клиническое значение

Производство CRTC1 блокируется при болезни Альцгеймера . ^{[ 11 ]}

Смотрите также

Целью транскрипции

Ссылки

^ Jump up to: ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105662 – Ensembl, May 2017
^ Jump up to: ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003575 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye FJ (Feb 2003). "t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway". Nature Genetics. 33 (2): 208–13. doi:10.1038/ng1083. PMID 12539049. S2CID 23417795.
^ Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (Aug 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell. 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
^ Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA (Oct 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.
^ "Entrez Gene: CRTC1 CREB regulated transcription coactivator 1".
^ Huret J-L. "CRTC1 (CREB regulated transcription coactivator 1)". Atlas of Genetics and Cytogenetics in Oncology and Haematology. INSERM U 935, Genetics, Dept Medical Information, University Hospital of Poitiers.
^ Kovács KA, Steullet P, Steinmann M, Do KQ, Magistretti PJ, Halfon O, Cardinaux JR (Mar 2007). "TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity". Proceedings of the National Academy of Sciences of the United States of America. 104 (11): 4700–5. Bibcode:2007PNAS..104.4700K. doi:10.1073/pnas.0607524104. PMC 1838663. PMID 17360587.
^ Parra-Damas A, Valero J, Chen M, España J, Martín E, Ferrer I, Rodríguez-Alvarez J, Saura CA (Apr 2014). "Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages". The Journal of Neuroscience. 34 (17): 5776–87. doi:10.1523/JNEUROSCI.5288-13.2014. PMC 6608295. PMID 24760838.

Внешние ссылки

CRTC1+белок,+человек в Национальной медицинской библиотеке Медицинской библиотеки США (Mesh)
человека Расположение генома CRTC1 и CRTC1 страница сведений генов в браузере генома UCSC .

Эта статья включает в себя текст из Национальной медицины Соединенных Штатов , которая находится в общественном достоянии .

Эта статья о гене о хромосоме человека 19 является заглушкой . Вы можете помочь Википедии, расширив ее .

[refGRCh38Ensembl-1] Jump up to: ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105662 – Ensembl, May 2017

[refGRCm38Ensembl-2] Jump up to: ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003575 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12539049-5] Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye FJ (Feb 2003). "t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway". Nature Genetics. 33 (2): 208–13. doi:10.1038/ng1083. PMID 12539049. S2CID 23417795.

[pmid14536081-6] Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (Aug 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell. 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.

[pmid14506290-7] Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA (Oct 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.

[entrez-8] "Entrez Gene: CRTC1 CREB regulated transcription coactivator 1".

[url_CRTC1_Atlas-9] Huret J-L. "CRTC1 (CREB regulated transcription coactivator 1)". Atlas of Genetics and Cytogenetics in Oncology and Haematology. INSERM U 935, Genetics, Dept Medical Information, University Hospital of Poitiers.

[pmid17360587-10] Kovács KA, Steullet P, Steinmann M, Do KQ, Magistretti PJ, Halfon O, Cardinaux JR (Mar 2007). "TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity". Proceedings of the National Academy of Sciences of the United States of America. 104 (11): 4700–5. Bibcode:2007PNAS..104.4700K. doi:10.1073/pnas.0607524104. PMC 1838663. PMID 17360587.

[pmid24760838-11] Parra-Damas A, Valero J, Chen M, España J, Martín E, Ferrer I, Rodríguez-Alvarez J, Saura CA (Apr 2014). "Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages". The Journal of Neuroscience. 34 (17): 5776–87. doi:10.1523/JNEUROSCI.5288-13.2014. PMC 6608295. PMID 24760838.

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v Т и Транскрипционные корегуляторы
Coactivators	ARA (54, 55, 70) BCAS3 CARM1 p300-CBP (EP300, CREBBP) CRTC (1, 2, 3) DRIP/TRAP (MED1 Drip205/Trap220) MN1 PCAF PNRC (1, 2) PPARGC (1A, 1B) TGFB1I1 NCOA1 (SRC-1) NCOA2 (GRIP1/SRC-2/TIF2) NCOA3 (AIB/SRC-3/TRAM-1) NCOA4 (ARA70) NCOA5 (CIA) NCOA6 (RAP250) NCOA7 (ERAP140)
Corepressors	CTBP (1, 2) Hairless homolog LCOR NRIP1 (RIP140) PELP-1 RCOR1 Rb SIN3A SIN3B Tripartite motif family TRIM (24, 28, 33) NCOR1 NCOR2 (SMRT)
ATP-dependent remodeling factors	Chromatin Structure Remodeling (RSC) Complex SWI/SNF

Клиническое значение

Смотрите также

Ссылки

Further reading

Внешние ссылки