Хромобластомикоз
| Хромобластомикоз | |
|---|---|
| Другие имена | Хромомикоз, [ 1 ] Кладопиоз, [ 1 ] Болезнь Фонсеки, [ 1 ] Болезнь Педрозо, [ 1 ] Феоспоротрихоз, [ 1 ] или вернукный дерматит [ 1 ] |
 | |
| Микрофотография хромобластомикоза, показывающая склеротические тела | |
| Специальность | Инфекционные заболевания , дерматология |
Хромобластомикоз -это долгосрочная грибковая инфекция кожи [ 2 ] и подкожная ткань ( хронический подкожный микоз ). [ 3 ]
Это может быть вызвано многими различными видами грибов , которые имплантируются под кожу , часто шипами или осколками. [ 4 ] Хромобластомикоз распространяется очень медленно. [ Цитация необходима ]
Это редко смертельно и обычно имеет хороший прогноз , но это может быть очень трудно вылечить. Несколько вариантов лечения включают лекарства и операцию. [ 5 ]
Инфекция чаще всего происходит в тропическом или субтропическом климате, часто в сельской местности. [ 6 ]
Симптомы и признаки
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The initial trauma causing the infection is often forgotten or not noticed. The infection builds at the site over a period of years, and a small red papule (skin elevation) appears. The lesion is usually not painful, with few, if any symptoms. Patients rarely seek medical care at this point.[citation needed]
Several complications may occur. Usually, the infection slowly spreads to the surrounding tissue while still remaining localized to the area around the original wound. However, sometimes the fungi may spread through the blood vessels or lymph vessels, producing metastatic lesions at distant sites. Another possibility is secondary infection with bacteria. This may lead to lymph stasis (obstruction of the lymph vessels) and elephantiasis. The nodules may become ulcerated, or multiple nodules may grow and coalesce, affecting a large area of a limb.[citation needed]
Cause
[edit]Chromoblastomycosis is believed to originate in minor trauma to the skin, usually from vegetative material such as thorns or splinters; this trauma implants fungi in the subcutaneous tissue. In many cases, the patient will not notice or remember the initial trauma, as symptoms often do not appear for years. The fungi most commonly observed to cause chromoblastomycosis are:
- Fonsecaea pedrosoi[8][9]
- Cladophialophora bantiana causes both cutaneous chromoblastomycosis and systemic phaeohyphomycosis
- Phialophora verrucosa[10]
- Cladophialophora carrionii
- Fonsecaea compacta[11]
Mechanism
[edit]Over months to years, an erythematous papule appears at the site of inoculation. Although the mycosis slowly spreads, it usually remains localized to the skin and subcutaneous tissue. Hematogenous and/or lymphatic spread may occur. Multiple nodules may appear on the same limb, sometimes coalescing into a large plaque. Secondary bacterial infection may occur, sometimes inducing lymphatic obstruction. The central portion of the lesion may heal, producing a scar, or it may ulcerate.[citation needed]
Diagnosis
[edit]The most informative test is to scrape the lesion and add potassium hydroxide (KOH), then examine under a microscope. (KOH scrapings are commonly used to examine fungal infections.) The pathognomonic finding is observing medlar bodies (also called muriform bodies or sclerotic cells). Scrapings from the lesion can also be cultured to identify the organism involved. Blood tests and imaging studies are not commonly used. On histology, chromoblastomycosis manifests as pigmented yeasts resembling "copper pennies". Special stains, such as periodic acid schiff and Gömöri methenamine silver, can be used to demonstrate the fungal organisms if needed.[citation needed]
Prevention
[edit]No preventive measure is known aside from avoiding the traumatic inoculation of fungi. At least one study found a correlation between walking barefoot in endemic areas and occurrence of chromoblastomycosis on the foot.[citation needed]
Treatment
[edit]Chromoblastomycosis is very difficult to cure. The primary treatments of choice are:[citation needed]
- Itraconazole, an antifungal azole, is given orally, with or without flucytosine.
- Alternatively, cryosurgery with liquid nitrogen has also been shown to be effective.
Other treatment options are the antifungal drug terbinafine,[12] another antifungal azole posaconazole, and heat therapy.
Antibiotics may be used to treat bacterial superinfections.[citation needed]
Amphotericin B has also been used.[13]
Photodynamic therapy is a newer type of therapy used to treat Chromblastomycosis.[14]
Prognosis
[edit]The prognosis for chromoblastomycosis is very good for small lesions. Severe cases are difficult to cure, although the prognosis is still quite good. The primary complications are ulceration, lymphedema, and secondary bacterial infection. A few cases of malignant transformation to squamous cell carcinoma have been reported. Chromoblastomycosis is very rarely fatal.[citation needed]
Epidemiology
[edit]Chromoblastomycosis occurs around the world, most commonly in rural areas in tropical or subtropical climates.[6]
It is most common in rural areas between approximately 30°N and 30°S latitude. Over two-thirds of patients are male, and usually between the ages of 30 and 50. A correlation with HLA-A29 suggests genetic factors may play a role, as well.[15]
Social and cultural
[edit]Chromoblastomycosis is considered a neglected tropical disease, affects mainly people living in poverty, and causes considerable morbidity, stigma and discrimination.[6]
See also
[edit]References
[edit]- ^ Jump up to: a b c d e f Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
- ^ "chromoblastomycosis" at Dorland's Medical Dictionary
- ^ López Martínez R, Méndez Tovar LJ (2007). "Chromoblastomycosis". Clin. Dermatol. 25 (2): 188–94. doi:10.1016/j.clindermatol.2006.05.007. PMID 17350498.
- ^ "Chromoblastomycosis | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program". rarediseases.info.nih.gov. Archived from the original on 2021-03-18. Retrieved 2018-04-17.
- ^ "Chromoblastomycosis | DermNet New Zealand". www.dermnetnz.org. Retrieved 2018-04-17.
- ^ Jump up to: a b c Santos, Daniel Wagner C. L.; de Azevedo, Conceição de Maria Pedrozo E. Silva; Vicente, Vania Aparecida; Queiroz-Telles, Flávio; Rodrigues, Anderson Messias; de Hoog, G. Sybren; Denning, David W.; Colombo, Arnaldo Lopes (August 2021). "The global burden of chromoblastomycosis". PLOS Neglected Tropical Diseases. 15 (8): e0009611. doi:10.1371/journal.pntd.0009611. ISSN 1935-2735. PMC 8360387. PMID 34383752.
- ^ Ran Yuping (2016). "Observation of Fungi, Bacteria, and Parasites in Clinical Skin Samples Using Scanning Electron Microscopy". In Janecek, Milos; Kral, Robert (eds.). Modern Electron Microscopy in Physical and Life Sciences. InTech. doi:10.5772/61850. ISBN 978-953-51-2252-4. S2CID 53472683.
- ^ Bonifaz A, Carrasco-Gerard E, Saúl A (2001). «Хромобластомикоз: клинический и микологический опыт 51 случая». Микозы . 44 (1–2): 1–7. doi : 10.1046/j.1439-0507.2001.00613.x . PMID 11398635 . S2CID 9606451 .
- ^ De Andrade TS, Cury AE, De Castro LG, Hirata MH, Hirata Rd (март 2007 г.). «Быстрая идентификация Fonsecaea дуплексной полимеразной цепной реакцией у изолятов от пациентов с хромобластомикозом». Диагноз Микробиол. Инфекция Диск . 57 (3): 267–72. doi : 10.1016/j.diagmicrobio.2006.08.024 . PMID 17338941 .
- ^ Park SG, OH SH, SUH SB, Lee KH, Chung KY (март 2005 г.). «Случай хромобластомикоза с необычным клиническим проявлением, вызванным Phialophora verrucosa в непрерывной области: лечение с комбинацией амфотерицина B и 5-флюцитозина». Бренд J. Dermatol . 152 (3): 560–4. doi : 10.1111/j.1365-2133.2005.06424.x . PMID 15787829 . S2CID 41788722 .
- ^ Attapattu MC (1997). «Хромобластомикоз-клиническое и микологическое исследование 71 случая из Шри-Ланки». Микопатология . 137 (3): 145–51. doi : 10.1023/a: 1006819530825 . PMID 9368408 . S2CID 26091759 .
- ^ Bonifaz A, Saúl A, Paredes-Solis V, Araiza J, Fierro-Arias L (февраль 2005 г.). «Лечение хромобластомикоза тербинафином: опыт с четырьмя случаями» . J Дерматолог лечит . 16 (1): 47–51. doi : 10.1080/095466630410024538 . PMID 15897168 . S2CID 45956388 .
- ^ Paniz-Mondolfi AE, Colella MT, Negrín DC (март 2008 г.). «Обширный хромобластомикоз, вызванный Fonsecaea Pedrosoi, успешно лечился сочетанием амфотерицина B и итраконазола» . Медик Микол . 46 (2): 179–84. doi : 10.1080/13693780701721856 . PMID 18324498 .
- ^ Queiroz-Telles, Flavio; De Cl Santos, Daniel Wagner (2013-06-01). «Проблемы в терапии хромобластомикоза» . Микопатология . 175 (5): 477–488. doi : 10.1007/s11046-013-9648-x . ISSN 1573-0832 . PMID 23636730 . S2CID 14417993 .
- ^ Queiroz-Leles, Flavio; Из Хуга, Сибрен; Сантос, Даниэль Вагнер Кл; Сальгадо, Клаудио Гедес; Висенте, Ваня Апарецида; Бонифаз, Александро; Ройлайд, Эммануэль; Си, Лиян; Азеведо, Консеич де Мария Педрозо Э. Сильва; Да Силва, Моизес Батиста; Пана, Зоя Доротея (январь 2017 г.). «Хромобластомикоз» . Клинические обзоры микробиологии . 30 (1): 233–276. Doi : 10.1128/cmr.00032-16 . ISSN 1098-6618 . PMC 5217794 . PMID 27856522 .
Внешние ссылки
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