Электронейтральный бикарбонатный обменник 1 натрия 1

SLC4A8
Идентификаторы
Псевдонимы	SLC4A8 , NBC3, NDCBE, Family Carrier Family 4 Член 4 8 Член 8
Внешние идентификаторы	Омим : 605024 ; MGI : 1928745 ; Гомологен : 68419 ; GeneCards : SLC4A8 ; OMA : SLC4A8 - ортологи
showМестоположение гена ( человек )
Chr.	Chromosome 12 (human)
End	51,515,763 bp
showМестоположение гена ( мышь )
Chr.	Chromosome 15 (mouse)
End	100,721,849 bp
showРНК -паттерн экспрессии
	Top expressed in
	pons; ; Brodmann area 23; ; superior vestibular nucleus; ; corpus callosum; ; middle temporal gyrus; ; ventral tegmental area; ; postcentral gyrus; ; inferior ganglion of vagus nerve; ; lateral nuclear group of thalamus; ; cerebellar vermis;
	Top expressed in
	spermatocyte; ; spermatid; ; zygote; ; neural layer of retina; ; secondary oocyte; ; lumbar subsegment of spinal cord; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; primary oocyte; ; cerebellar cortex;
	More reference expression data
	More reference expression data
showДжин Онтология
Molecular function	antiporter activity; inorganic anion exchanger activity; anion transmembrane transporter activity; sodium:bicarbonate symporter activity;
Cellular component	integral component of membrane; neuronal cell body membrane; neuron projection; plasma membrane; membrane; integral component of plasma membrane;
Biological process	anion transport; sodium ion transport; regulation of intracellular pH; inorganic anion transport; ion transport; bicarbonate transport; transmembrane transport; anion transmembrane transport;
	Sources:Amigo / QuickGO
hideOrthologs
	9498
	59033
	ENSG00000050438
	ENSMUSG00000023032
	Q2Y0W8
	Q8JZR6
showNM_001039960; NM_001258401; NM_001258402; NM_001258403; NM_001267615;
	NM_004858; NM_001405266; NM_001405268; NM_001405270
	NM_001033218; NM_021530; NM_001347102
	NP_001035049; NP_001245330; NP_001245331; NP_001245332; NP_001254544
	NP_001334031; NP_067505
	Wikidata
View/Edit Human	View/Edit Mouse

Электронейтральный бикарбонатный обменник 1 натрия 1 - это белок , который у людей кодируется SLC4A8 геном . ^{[ 5 ]}^{[ 6 ]}

Смотрите также

Взаимодействия

Было показано, что SLC4A8 взаимодействует с регулятором 1 натрия-гидрогенового антипортера 3 ^{[ 7 ]}^{[ 8 ]} и регулятор трансмембранного проводимости муковисцидоза . ^{[ 8 ]}

Ссылки

^ Jump up to: ^а ^{беременный} ^в GRCH38: Ensembl Release 89: ENSG00000050438 - Ensembl , май 2017 г.
^ Jump up to: ^а ^{беременный} ^в GRCM38: Ensembl Release 89: Ensmusg00000023032 - Ensembl , май 2017 г.
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Grichtchenko II, Choi I, Zhong X, Bray-Ward P, Russell JM, Boron WF (May 2001). "Cloning, characterization, and chromosomal mapping of a human electroneutral Na⁺-driven Cl⁻HCO₃ exchanger". J Biol Chem. 276 (11): 8358–63. doi:10.1074/jbc.C000716200. PMID 11133997.
^ "Entrez Gene: SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8".
^ Pushkin A, Abuladze N, Newman D, Muronets V, Sassani P, Tatishchev S, Kurtz I (March 2003). "The COOH termini of NBC3 and the 56-kDa H⁺-ATPase subunit are PDZ motifs involved in their interaction". Am. J. Physiol., Cell Physiol. 284 (3): C667–73. doi:10.1152/ajpcell.00225.2002. PMID 12444018. S2CID 7070088.
^ Jump up to: ^a ^b Park M, Ko SB, Choi JY, Muallem G, Thomas PJ, Pushkin A, Lee MS, Kim JY, Lee MG, Muallem S, Kurtz I (December 2002). "The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO₃⁻ salvage transporter human Na⁺-HCO₃⁻ cotransport isoform 3". J. Biol. Chem. 277 (52): 50503–9. doi:10.1074/jbc.M201862200. PMID 12403779.

Soleimani M (2002). "Na⁺:HCO₃⁻ cs (NBC): expression and regulation in the kidney". J. Nephrol. 15 (Suppl 5): S32–40. PMID 12027220.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Loiselle FB, Morgan PE, Alvarez BV, Casey JR (2004). "Regulation of the human NBC3 Na⁺/HCO₃⁻ cotransporter by carbonic anhydrase II and PKA". Am. J. Physiol., Cell Physiol. 286 (6): C1423–33. doi:10.1152/ajpcell.00382.2003. PMID 14736710.
Pushkin A, Abuladze N, Newman D, Muronets V, Sassani P, Tatishchev S, Kurtz I (2003). "The COOH termini of NBC3 and the 56-kDa H⁺-ATPase subunit are PDZ motifs involved in their interaction". Am. J. Physiol., Cell Physiol. 284 (3): C667–73. doi:10.1152/ajpcell.00225.2002. PMID 12444018. S2CID 7070088.
Park M, Ko SB, Choi JY, Muallem G, Thomas PJ, Pushkin A, Lee MS, Kim JY, Lee MG, Muallem S, Kurtz I (2003). "The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO₃⁻ salvage transporter human Na⁺-HCO₃⁻ cotransport isoform 3". J. Biol. Chem. 277 (52): 50503–9. doi:10.1074/jbc.M201862200. PMID 12403779.
Gresz V, Kwon TH, Vorum H, Zelles T, Kurtz I, Steward MC, Aalkjaer C, Nielsen S (2002). "Immunolocalization of electroneutral Na⁺-HCO cotransporters in human and rat salivary glands". Am. J. Physiol. Gastrointest. Liver Physiol. 283 (2): G473–80. doi:10.1152/ajpgi.00421.2001. PMID 12121896.
Amlal H, Burnham CE, Soleimani M (1999). "Характеристика Na ⁺/HCO ₃⁻ Изоформа котранспортера NBC-3 ". Am. J. Physiol . 276 (6 Pt 2): F903–13. DOI : 10.1152/ajprenal.1999.276.6.f903 . PMID 10362779 .
Пушкин А., Абуладзе Н., Ли I, Ньюман Д., Хван Дж., Курц И. (1999). «Клонирование, распределение тканей, геномная организация и функциональная характеристика NBC3, нового члена семейства котранспортеров натрия» . Дж. Биол. Химический 274 (23): 16569–75. doi : 10.1074/jbc.274.23.16569 . PMID 10347222 .
Нагасе Т., Ишикава К., Суяма М., Кикуно Р., Мияджима Н., Танака А., Котани Х, Номура Н., Охара О (1999). «Прогнозирование кодирующих последовательностей неопознанных генов человека. XI. Полные последовательности 100 новых клонов кДНК из мозга, которые код для крупных белков in vitro» . ДНК Res . 5 (5): 277–86. doi : 10.1093/dnares/5.5.277 . PMID 9872452 .

Эта статья, связанная с мембранным белком, является заглушкой . Вы можете помочь Википедии, расширив ее .

[refGRCh38Ensembl-1] Jump up to: ^а ^{беременный} ^в GRCH38: Ensembl Release 89: ENSG00000050438 - Ensembl , май 2017 г.

[refGRCm38Ensembl-2] Jump up to: ^а ^{беременный} ^в GRCM38: Ensembl Release 89: Ensmusg00000023032 - Ensembl , май 2017 г.

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11133997-5] Grichtchenko II, Choi I, Zhong X, Bray-Ward P, Russell JM, Boron WF (May 2001). "Cloning, characterization, and chromosomal mapping of a human electroneutral Na⁺-driven Cl⁻HCO₃ exchanger". J Biol Chem. 276 (11): 8358–63. doi:10.1074/jbc.C000716200. PMID 11133997.

[entrez-6] "Entrez Gene: SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8".

[pmid12444018-7] Pushkin A, Abuladze N, Newman D, Muronets V, Sassani P, Tatishchev S, Kurtz I (March 2003). "The COOH termini of NBC3 and the 56-kDa H⁺-ATPase subunit are PDZ motifs involved in their interaction". Am. J. Physiol., Cell Physiol. 284 (3): C667–73. doi:10.1152/ajpcell.00225.2002. PMID 12444018. S2CID 7070088.

[pmid12403779-8] Jump up to: ^a ^b Park M, Ko SB, Choi JY, Muallem G, Thomas PJ, Pushkin A, Lee MS, Kim JY, Lee MG, Muallem S, Kurtz I (December 2002). "The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO₃⁻ salvage transporter human Na⁺-HCO₃⁻ cotransport isoform 3". J. Biol. Chem. 277 (52): 50503–9. doi:10.1074/jbc.M201862200. PMID 12403779.

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Смотрите также

Взаимодействия

Ссылки

Further reading