Пассивное курение

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Табачный дым в ирландском пабе до запрета на курение , 29 марта 2004 г. вступления в силу

Пассивное курение — это вдыхание табачного дыма , называемого пассивным курением , пассивным курением ( SHS ) или табачным дымом окружающей среды ( ETS ), лицами, не являющимися активными курильщиками . Это происходит, когда табачный дым распространяется в окружающую атмосферу в виде аэрозольного загрязнителя , что приводит к его вдыханию окружающими людьми в той же среде. Воздействие пассивного табачного дыма вызывает во многом такие же последствия для здоровья, как и активное курение . хотя и с меньшей распространенностью из-за пониженной концентрации дыма, попадающего в дыхательные пути .

Согласно последнему докладу ВОЗ, ежегодно во всем мире пассивное курение приводит к более чем 1,3 миллиона смертей. Риски для здоровья, связанные с пассивным курением, являются предметом научного консенсуса . и были основным мотивом для введения запрета на курение на рабочих местах и ​​в закрытых помещениях, включая рестораны , бары и ночные клубы , а также в некоторых открытых общественных местах .

Обеспокоенность по поводу пассивного курения сыграла центральную роль в дебатах о вреде и регулировании табачных изделий. С начала 1970-х годов табачная промышленность рассматривала обеспокоенность общественности по поводу пассивного курения как серьезную угрозу своим деловым интересам. Несмотря на осознание табачной промышленностью вреда пассивного курения еще в 1980-х годах, табачная промышленность координировала научную полемику с целью прекращения регулирования своей продукции.

Терминология

Фриц Ликинт ввел термин «пассивное курение» («Passivrauchen») в публикации на немецком языке в 1930-х годах. Используемые термины включают «табачный дым в окружающей среде» для обозначения переносимых по воздуху веществ, а «непроизвольное курение» и «пассивное курение» относятся к воздействию пассивного курения. Термин «табачный дым в окружающей среде» восходит к спонсируемому промышленностью совещанию 1974 года, состоявшемуся на Бермудских островах , а термин «пассивное курение» впервые был использован в названии научной статьи в 1970 году. Главный хирург США предпочитает использовать фразу «пассивное курение», а не «табачный дым в окружающей среде», заявляя, что «дескриптор «пассивное курение» отражает непроизвольный характер воздействия, а слово «окружающий» - нет». Большинство исследователей считают термин «пассивное курение» синонимом «пассивного курения». Напротив, в комментарии 2011 года в журнале Environmental Health Perspectives утверждается, что исследование «третьего курения» делает неуместным называть пассивное курение термином «пассивное курение», который, по мнению авторов, представляет собой pars pro toto .

Термин « побочный дым » иногда используется для обозначения дыма, который выходит в воздух непосредственно из горящей сигареты , сигары или трубки . в то время как «основной дым» относится к дыму, который выдыхает курильщик.

Влияние на здоровье

Пассивное курение вызывает многие из тех же заболеваний, что и прямое курение , включая сердечно-сосудистые заболевания , рак легких и респираторные заболевания . К ним относятся:

• Рак :
  • Общие: общий повышенный риск; Анализируя данные, накопленные во всем мире, Международное агентство по исследованию рака в 2004 году пришло к выводу, что «вынужденное курение (воздействие пассивного или «экологического» табачного дыма) канцерогенно для человека». Центры по контролю и профилактике заболеваний сообщают, что около 70 химических веществ, присутствующих в пассивном курении, являются канцерогенными.
  • Рак легких : Пассивное курение является фактором риска рака легких. По оценкам, в Соединенных Штатах пассивное курение является причиной более 7000 смертей от рака легких в год среди некурящих. Четверть всех случаев приходится на людей, которые никогда не курили.
  • Рак молочной железы : Калифорнийское агентство по охране окружающей среды в 2005 году пришло к выводу, что пассивное курение увеличивает риск рака молочной железы у более молодых женщин, преимущественно в пременопаузе, на 70%. США и главный хирург пришел к выводу, что доказательства являются «наводящими на размышления», но все же недостаточными, чтобы утверждать такую ​​причинно-следственную связь. Напротив, Международное агентство по исследованию рака в 2004 году пришло к выводу, что «не существует причинно-следственной связи между непроизвольным воздействием табачного дыма и раком молочной железы у никогда не куривших». Метаанализ 2015 года показал, что доказательства того, что пассивное курение умеренно увеличивает риск рака молочной железы, стали «более существенными, чем несколько лет назад».
  • Рак шейки матки : обзор систематических обзоров 2015 года показал, что пассивное курение увеличивает риск развития рака шейки матки.
  • Рак мочевого пузыря : систематический обзор и метаанализ 2016 года показали, что пассивное курение связано со значительным увеличением риска развития рака мочевого пузыря.
• Система кровообращения : риск сердечно-сосудистых заболеваний и снижение вариабельности сердечного ритма.
  • Эпидемиологические исследования показали, что как активное, так и пассивное курение сигарет увеличивает риск развития атеросклероза.
  • Пассивное курение тесно связано с повышенным риском инсульта, и этот повышенный риск непропорционально высок при низких уровнях воздействия.
• Проблемы с легкими :
  • Риск астмы
  • Риск хронической обструктивной болезни легких (ХОБЛ)
  • Согласно обзору 2015 года, пассивное курение может увеличить риск заражения туберкулезом и ускорить прогрессирование заболевания, но доказательства остаются слабыми.
  • Большинство исследований связи между пассивным курением и синуситом выявили значительную связь между ними.
• Когнитивные нарушения и деменция . Воздействие пассивного курения может повысить риск когнитивных нарушений и деменции у взрослых в возрасте 50 лет и старше. У детей, подвергшихся пассивному курению, наблюдается снижение словарного запаса и навыков рассуждения по сравнению с детьми, не подвергавшимися воздействию табачного дыма, а также более общие когнитивные и интеллектуальные нарушения.
• Психическое здоровье . Воздействие пассивного курения связано с повышенным риском развития симптомов депрессии.
• Во время беременности :
  • Выкидыш : метаанализ 2014 года показал, что пассивное курение матери увеличивает риск выкидыша на 11%.
  • Низкий вес при рождении ^{, часть Б, гл. 3} .
  • Преждевременные роды ^{, часть Б, гл. 3} (Доказательства причинно-следственной связи описаны главным хирургом США в его отчете за 2006 год только как «наводящие на размышления». ) Законы, ограничивающие курение, снижают число преждевременных родов.
  • Мертворождение и врожденные пороки развития у детей
  • Недавние исследования, сравнивающие женщин, подвергшихся пассивному курению, и женщин, не подвергавшихся воздействию табачного дыма, показывают, что женщины, подвергшиеся воздействию табачного дыма во время беременности, имеют более высокий риск рождения ребенка с врожденными аномалиями, большей длиной тела, меньшими окружностями головы и дефектами нервной трубки .
• Общий:
  • Обострение астмы, аллергии и других состояний. Систематический обзор и метаанализ 2014 года показали, что пассивное курение связано с несколько повышенным риском аллергических заболеваний среди детей и подростков; доказательства связи были слабее для взрослых.
  • Диабет 2 типа . Остается неясным, является ли связь между пассивным курением и диабетом причинной.
• Риск переноса Neisseria meningitidis или Streptococcus pneumoniae .
• Возможный повышенный риск пародонтита .
• Общий повышенный риск смерти у обоих взрослых: по оценкам, в 1991 году в США от него погибало 53 000 некурящих в год. и у детей. Всемирная организация здравоохранения заявляет, что пассивное курение является причиной около 600 000 смертей в год и составляет около 1% глобального бремени болезней. По состоянию на 2017 год пассивное курение является причиной около 900 000 смертей в год, что составляет около 1/8 всех смертей, вызванных курением.
• Кожные заболевания: систематический обзор и метаанализ 2016 года показали, что пассивное курение связано с более высоким уровнем развития атопического дерматита .

Риск для детей

• Синдром внезапной детской смерти (СВДС). В своем отчете за 2006 год главный хирург США заключает: «Доказательств достаточно, чтобы сделать вывод о причинно-следственной связи между воздействием пассивного курения и синдромом внезапной детской смерти». По оценкам, пассивное курение является причиной 430 смертей от СВДС в Соединенных Штатах ежегодно.
• Астма . Воздействие пассивного курения также связано с почти удвоенным риском госпитализации по поводу обострения астмы среди детей с астмой.
• Легочные инфекции, также включая более тяжелое заболевание с бронхиолитом и бронхит , и худший исход, а также повышенный риск развития туберкулеза при контакте с носителем. По оценкам, в Соединенных Штатах пассивное курение связано с от 150 000 до 300 000 инфекций нижних дыхательных путей у младенцев и детей в возрасте до 18 месяцев, что приводит к от 7 500 до 15 000 госпитализаций каждый год.
• Impaired respiratory function and slowed lung growth
• Allergies
• Maternal passive smoking increases the risk of non-syndromic orofacial clefts by 50% among their children.
• Learning difficulties, developmental delays, executive function problems, and neurobehavioral effects. Animal models suggest a role for nicotine and carbon monoxide in neurocognitive problems.
• An increase in tooth decay (as well as related salivary biomarkers) has been associated with passive smoking in children.
• Increased risk of middle ear infections.
• Invasive meningococcal disease.
• Anesthesia complications and some negative surgical outcomes.
• Sleep disordered breathing: Most studies have found a significant association between passive smoking and sleep disordered breathing in children, but further studies are needed to determine whether this association is causal.
• Adverse effects on the cardiovascular system of children.

Evidence

Exposure to secondhand smoke by age, race, and poverty level in the US in 2010

Epidemiological studies show that non-smokers exposed to secondhand smoke are at risk for many of the health problems associated with direct smoking.

In 1992, a review estimated that secondhand smoke exposure was responsible for 35,000 to 40,000 deaths per year in the United States in the early 1980s. The absolute risk increase of heart disease due to ETS was 2.2%, while the attributable risk percent was 23%. A 1997 meta-analysis found that secondhand smoke exposure increased the risk of heart disease by a quarter, and two 1999 meta-analyses reached similar conclusions.

Evidence shows that inhaled sidestream smoke, the main component of secondhand smoke, is about four times more toxic than mainstream smoke. This fact has been known to the tobacco industry since the 1980s, though it kept its findings secret. Some scientists believe that the risk of passive smoking, in particular the risk of developing coronary heart diseases, may have been substantially underestimated.

In 1997, a meta-analysis on the relationship between secondhand smoke exposure and lung cancer concluded that such exposure caused lung cancer. The increase in risk was estimated to be 24% among non-smokers who lived with a smoker. In 2000, Copas and Shi reported that there was clear evidence of publication bias in the studies included in this meta-analysis. They further concluded that after correcting for publication bias, and assuming that 40% of all studies are unpublished, this increased risk decreased from 24% to 15%. This conclusion has been challenged on the basis that the assumption that 40% of all studies are unpublished was "extreme". In 2006, Takagi et al. reanalyzed the data from this meta-analysis to account for publication bias and estimated that the relative risk of lung cancer among those exposed to secondhand smoke was 1.19, slightly lower than the original estimate. A 2000 meta-analysis found a relative risk of 1.48 for lung cancer among men exposed to secondhand smoke, and a relative risk of 1.16 among those exposed to it at work. Another meta-analysis confirmed the finding of an increased risk of lung cancer among women with spousal exposure to secondhand smoke the following year. It found a relative risk of lung cancer of 1.29 for women exposed to secondhand smoke from their spouses. A 2014 meta-analysis noted that "the association between exposure to secondhand smoke and lung cancer risk is well established."

A minority of epidemiologists have found it hard to understand how secondhand smoke, which is more diluted than actively inhaled smoke, could have an effect that is such a large fraction of the added risk of coronary heart disease among active smokers. One proposed explanation is that secondhand smoke is not simply a diluted version of "mainstream" smoke, but has a different composition with more toxic substances per gram of total particulate matter. Passive smoking appears to be capable of precipitating the acute manifestations of cardio-vascular diseases (atherothrombosis) and may also have a negative impact on the outcome of patients who have acute coronary syndromes.

In 2004, the International Agency for Research on Cancer (IARC) of the World Health Organization (WHO) reviewed all significant published evidence related to tobacco smoking and cancer. It concluded:

These meta-analyses show that there is a statistically significant and consistent association between lung cancer risk in spouses of smokers and exposure to second-hand tobacco smoke from the spouse who smokes. The excess risk is of the order of 20% for women and 30% for men and remains after controlling for some potential sources of bias and confounding.

Subsequent meta-analyses have confirmed these findings.

The National Asthma Council of Australia cites studies showing that secondhand smoke is probably the most important indoor pollutant, especially around young children:

• Smoking by either parent, particularly by the mother, increases the risk of asthma in children.
• The outlook for early childhood asthma is less favourable in smoking households.
• Children with asthma who are exposed to smoking in the home generally have more severe disease.
• Many adults with asthma identify ETS as a trigger for their symptoms.
• Doctor-diagnosed asthma is more common among non-smoking adults exposed to ETS than those not exposed. Among people with asthma, higher ETS exposure is associated with a greater risk of severe attacks.

In France, exposure to secondhand smoke has been estimated to cause between 3,000 and 5,000 premature deaths per year, with the larger figure cited by Prime Minister Dominique de Villepin during his announcement of a nationwide smoke-free law: "That makes more than 13 deaths a day. It is an unacceptable reality in our country in terms of public health."

There is good observational evidence that smoke-free legislation reduces the number of hospital admissions for heart disease.

Exposure and risk levels

The International Agency for Research on Cancer of the World Health Organization concluded in 2004 that there was sufficient evidence that secondhand smoke caused cancer in humans. Those who work in environments where smoke is not regulated are at higher risk. Workers particularly at risk of exposure include those in installation repair and maintenance, construction and extraction, and transportation.

Much research has come from studies of nonsmokers who are married to a smoker. The US Surgeon General, in his 2006 report, estimated that living or working in a place where smoking is permitted increases the non-smokers' risk of developing heart disease by 25–30% and lung cancer by 20–30%.

Similarly, children who are exposed to environmental tobacco smoke are shown to experience a range of adverse effects and a higher risk of becoming smokers later in life. The WHO has identified reduction of exposure to environmental tobacco smoke as key element for actions to encourage healthy child development.

The US Centers for Disease Control and Prevention monitors the extent of and trends in exposure to environmental tobacco smoke by measuring serum cotinine in national health surveys. The prevalence of secondhand smoke exposure among U.S. nonsmokers declined from 87.5% in 1988 to 25.2% in 2014. However, nearly half of blacks and the poor were exposed in 2014.

Interventions to reduce environmental tobacco smoke

A systematic review compared smoking control programmes and their effects on smoke exposure in children. The review distinguishes between community-based, ill-child and healthy-child settings and the most common types of interventions were counselling or brief advice during clinical visits. The review did not find superior outcomes for any intervention, and the authors caution that evidence from adult settings may not generalise well to children.

Biomarkers

Breath CO monitor displaying carbon monoxide concentration of an exhaled breath sample (in ppm) with corresponding percent concentration of carboxyhemoglobin displayed below

Environmental tobacco smoke can be evaluated either by directly measuring tobacco smoke pollutants found in the air or by using biomarkers, an indirect measure of exposure. Carbon monoxide monitored through breath, nicotine, cotinine, thiocyanates, and proteins are the most specific biological markers of tobacco smoke exposure. Biochemical tests are a much more reliable biomarker of secondhand smoke exposure than surveys. Certain groups of people are reluctant to disclose their smoking status and exposure to tobacco smoke, especially pregnant women and parents of young children. This is due to their smoking being socially unacceptable. Also, it may be difficult for individuals to recall their exposure to tobacco smoke.

A 2007 study in the Addictive Behaviors journal found a positive correlation between secondhand tobacco smoke exposure and concentrations of nicotine and/or biomarkers of nicotine in the body. Significant biological levels of nicotine from secondhand smoke exposure were equivalent to nicotine levels from active smoking and levels that are associated with behaviour changes due to nicotine consumption.

Cotinine

Cotinine, the metabolite of nicotine, is a biomarker of secondhand smoke exposure. Typically, cotinine is measured in the blood, saliva, and urine. Hair analysis has recently become a new, noninvasive measurement technique. Cotinine accumulates in hair during hair growth, which results in a measure of long-term, cumulative exposure to tobacco smoke. Urinary cotinine levels have been a reliable biomarker of tobacco exposure and have been used as a reference in many epidemiological studies. However, cotinine levels found in the urine reflect exposure only over the preceding 48 hours. Cotinine levels of the skin, such as the hair and nails, reflect tobacco exposure over the previous three months and are a more reliable biomarker.

Carbon monoxide (CO)

Carbon monoxide monitored via breath is also a reliable biomarker of secondhand smoke exposure as well as tobacco use. With high sensitivity and specificity, it not only provides an accurate measure, but the test is also non-invasive, highly reproducible, and low in cost. Breath CO monitoring measures the concentration of CO in an exhalation in parts per million, and this can be directly correlated to the blood CO concentration (carboxyhemoglobin). Breath CO monitors can also be used by emergency services to identify patients who are suspected of having CO poisoning.

Pathophysiology

A 2004 study by the International Agency for Research on Cancer of the World Health Organization concluded that non-smokers are exposed to the same carcinogens as active smokers. Sidestream smoke contains more than 4,000 chemicals, including 69 known carcinogens. Of special concern are polynuclear aromatic hydrocarbons, tobacco-specific N-nitrosamines, and aromatic amines, such as 4-aminobiphenyl, all known to be highly carcinogenic. Mainstream smoke, sidestream smoke, and secondhand smoke contain largely the same components, however the concentration varies depending on type of smoke. Several well-established carcinogens have been shown by the tobacco companies' own research to be present at higher concentrations in sidestream smoke than in mainstream smoke.

Secondhand smoke has been shown to produce more particulate-matter (PM) pollution than an idling low-emission diesel engine. In an experiment conducted by the Italian National Cancer Institute, three cigarettes were left smoldering, one after the other, in a 60 m³ garage with a limited air exchange. The cigarettes produced PM pollution exceeding outdoor limits, as well as PM concentrations up to 10-fold that of the idling engine.

Secondhand tobacco smoke exposure has immediate and substantial effects on blood and blood vessels in a way that increases the risk of a heart attack, particularly in people already at risk. Exposure to tobacco smoke for 30 minutes significantly reduces coronary flow velocity reserve in healthy nonsmokers. Secondhand smoke is also associated with impaired vasodilation among adult nonsmokers. Secondhand smoke exposure also affects platelet function, vascular endothelium, and myocardial exercise tolerance at levels commonly found in the workplace.

Pulmonary emphysema can be induced in rats through acute exposure to sidestream tobacco smoke (30 cigarettes per day) over a period of 45 days. Degranulation of mast cells contributing to lung damage has also been observed.

The term "third-hand smoke" was recently coined to identify the residual tobacco smoke contamination that remains after the cigarette is extinguished and secondhand smoke has cleared from the air. Preliminary research suggests that by-products of third-hand smoke may pose a health risk,though the magnitude of risk, if any, remains unknown. In October 2011, it was reported that Christus St. Frances Cabrini Hospital in Alexandria, Louisiana, would seek to eliminate third-hand smoke beginning in July 2012, and that employees whose clothing smelled of smoke would not be allowed to work. This prohibition was enacted because third-hand smoke poses a special danger for the developing brains of infants and small children.

In 2008, there were more than 161,000 deaths attributed to lung cancer in the United States. Of these deaths, an estimated 10% to 15% were caused by factors other than first-hand smoking; equivalent to 16,000 to 24,000 deaths annually. Slightly more than half of the lung cancer deaths caused by factors other than first-hand smoking were found in nonsmokers. Lung cancer in non-smokers may well be considered one of the most common cancer mortalities in the United States. Clinical epidemiology of lung cancer has linked the primary factors closely tied to lung cancer in non-smokers as exposure to secondhand tobacco smoke, carcinogens including radon, and other indoor air pollutants.

Opinion of public health authorities

There is widespread scientific consensus that exposure to secondhand smoke is harmful. The link between passive smoking and health risks is accepted by every major medical and scientific organisation, including:

• World Health Organization
• U.S. National Institutes of Health
• Centers for Disease Control
• United States Surgeon General
• U.S. National Cancer Institute
• United States Environmental Protection Agency
• California Environmental Protection Agency
• American Heart Association, American Lung Association, and American Cancer Society
• American Medical Association
• American Academy of Pediatrics
• Australian National Health and Medical Research Council
• United Kingdom Scientific Committee on Tobacco and Health

Public opinion

Recent major surveys conducted by the U.S. National Cancer Institute and Centers for Disease Control have found widespread public awareness that secondhand smoke is harmful. In both 1992 and 2000 surveys, more than 80% of respondents agreed with the statement that secondhand smoke was harmful. A 2001 study found that 95% of adults agreed that secondhand smoke was harmful to children, and 96% considered tobacco-industry claims that secondhand smoke was not harmful to be untruthful.

A 2007 Gallup poll found that 56% of respondents felt that secondhand smoke was "very harmful", a number that has held relatively steady since 1997. Another 29% believe that secondhand smoke is "somewhat harmful"; 10% answered "not too harmful", while 5% said "not at all harmful".

Controversy over harm

As part of its attempt to prevent or delay tighter regulation of smoking, the tobacco industry funded a number of scientific studies and, where the results cast doubt on the risks associated with secondhand smoke, sought wide publicity for those results. The industry also funded libertarian and conservative think tanks, such as the Cato Institute in the United States and the Institute of Public Affairs in Australia which criticised both scientific research on passive smoking and policy proposals to restrict smoking. New Scientist and the European Journal of Public Health have identified these industry-wide coordinated activities as one of the earliest expressions of corporate denialism. Further, they state that the disinformation spread by the tobacco industry has created a tobacco denialism movement, sharing many characteristics of other forms of denialism, such as HIV-AIDS denialism.

Industry-funded studies and critiques

Enstrom and Kabat

A 2003 study by James Enstrom and Geoffrey Kabat, published in the British Medical Journal, argued that the harms of passive smoking had been overstated. Their analysis reported no statistically significant relationship between passive smoking and lung cancer, coronary heart disease (CHD), or chronic obstructive pulmonary disease, though the accompanying editorial noted that "they may overemphasise the negative nature of their findings." This paper was widely promoted by the tobacco industry as evidence that the harms of passive smoking were unproven. The American Cancer Society (ACS), whose database Enstrom and Kabat used to compile their data, criticized the paper as "neither reliable nor independent", stating that scientists at the ACS had repeatedly pointed out serious flaws in Enstrom and Kabat's methodology prior to publication. Notably, the study had failed to identify a comparison group of "unexposed" persons.

Enstrom's ties to the tobacco industry also drew scrutiny; in a 1997 letter to Philip Morris, Enstrom requested a "substantial research commitment... in order for me to effectively compete against the large mountain of epidemiologic data and opinions that already exist regarding the health effects of ETS and active smoking." In a US racketeering lawsuit against tobacco companies, the Enstrom and Kabat paper was cited by the US District Court as "a prime example of how nine tobacco companies engaged in criminal racketeering and fraud to hide the dangers of tobacco smoke." The Court found that the study had been funded and managed by the Center for Indoor Air Research, a tobacco industry front group tasked with "offsetting" damaging studies on passive smoking, as well as by Philip Morris who stated that Enstrom's work was "clearly litigation-oriented". A 2005 paper in Tobacco Control argued that the disclosure section in the Enstrom and Kabat BMJ paper, although it met the journal's requirements, "does not reveal the full extent of the relationship the authors had with the tobacco industry."

In 2006, Enstrom and Kabat published a meta-analysis of studies regarding passive smoking and coronary heart disease in which they reported a very weak association between passive smoking and heart disease mortality. They concluded that exposure to secondhand smoke increased the risk of death from CHD by only 5%, although this analysis has been criticized for including two previous industry-funded studies that suffered from widespread exposure misclassification.

Gori

Gio Batta Gori, a tobacco industry spokesman and consultant and an expert on risk utility and scientific research, wrote in the libertarian Cato Institute's magazine Regulation that "...of the 75 published studies of ETS and lung cancer, some 70% did not report statistically significant differences of risk and are moot. Roughly 17% claim an increased risk and 13% imply a reduction of risk."

Milloy

Steven Milloy, the "junk science" commentator for Fox News and a former Philip Morris consultant, claimed that "of the 19 studies" on passive smoking "only 8— slightly more than 42%— reported statistically significant increases in heart disease incidence."

Another component of criticism cited by Milloy focused on relative risk and epidemiological practices in studies of passive smoking. Milloy, who has a master's degree from the Johns Hopkins School of Hygiene and Public Health, argued that studies yielding relative risks of less than 2 were meaningless junk science. This approach to epidemiological analysis was criticized in the American Journal of Public Health:

A major component of the industry attack was the mounting of a campaign to establish a "bar" for "sound science" that could not be fully met by most individual investigations, leaving studies that did not meet the criteria to be dismissed as "junk science."

The tobacco industry and affiliated scientists also put forward a set of "Good Epidemiology Practices" which would have the practical effect of obscuring the link between secondhand smoke and lung cancer; the privately stated goal of these standards was to "impede adverse legislation". However, this effort was largely abandoned when it became clear that no independent epidemiological organization would agree to the standards proposed by Philip Morris et al.

Levois and Layard

In 1995, Levois and Layard, both tobacco industry consultants, published two analyses in the journal Regulatory Toxicology and Pharmacology regarding the association between spousal exposure to secondhand smoke and heart disease. Both of these papers reported no association between secondhand smoke and heart disease. These analyses have been criticized for failing to distinguish between current and former smokers, despite the fact that former smokers, unlike current ones, are not at a significantly increased risk of heart disease.

World Health Organization controversy

A 1998 study by the International Agency for Research on Cancer (IARC) on environmental tobacco smoke (ETS) found "weak evidence of a dose–response relationship between risk of lung cancer and exposure to spousal and workplace ETS."

In March 1998, before the study was published, reports appeared in the media alleging that the IARC and the World Health Organization (WHO) were suppressing information. The reports, appearing in the British Sunday Telegraph and The Economist, among other sources, alleged that the WHO withheld from publication of its own report that supposedly failed to prove an association between passive smoking and a number of other diseases (lung cancer in particular).

In response, the WHO issued a press release stating that the results of the study had been "completely misrepresented" in the popular press and were in fact very much in line with similar studies demonstrating the harms of passive smoking. The study was published in the Journal of the National Cancer Institute in October of the same year, and concluded the authors found "no association between childhood exposure to ETS and lung cancer risk" but "did find weak evidence of a dose–response relationship between risk of lung cancer and exposure to spousal and workplace ETS." An accompanying editorial summarized:

When all the evidence, including the important new data reported in this issue of the Journal, is assessed, the inescapable scientific conclusion is that ETS is a low-level lung carcinogen.

With the release of formerly classified tobacco industry documents through the Tobacco Master Settlement Agreement, it was found (by Elisa Ong and Stanton Glantz) that the controversy over the WHO's alleged suppression of data had been engineered by Philip Morris, British American Tobacco, and other tobacco companies in an effort to discredit scientific findings which would harm their business interests. A WHO inquiry, conducted after the release of the tobacco-industry documents, found that this controversy was generated by the tobacco industry as part of its larger campaign to cut the WHO's budget, distort the results of scientific studies on passive smoking, and discredit the WHO as an institution. This campaign was carried out using a network of ostensibly independent front organizations and international and scientific experts with hidden financial ties to the industry.

EPA lawsuit

In 1993, the United States Environmental Protection Agency (EPA) issued a report estimating that 3,000 lung cancer related deaths in the United States were caused by passive smoking annually.

Philip Morris, R.J. Reynolds Tobacco Company, and groups representing growers, distributors and marketers of tobacco took legal action, claiming that the EPA had manipulated this study and ignored accepted scientific and statistical practices.

The United States District Court for the Middle District of North Carolina ruled in favor of the tobacco industry in 1998, finding that the EPA had failed to follow proper scientific and epidemiologic practices and had "cherry picked" evidence to support conclusions which they had committed to in advance. The court stated in part, "EPA publicly committed to a conclusion before research had begun...adjusted established procedure and scientific norms to validate the Agency's public conclusion... In conducting the ETS Risk Assessment, disregarded information and made findings on selective information; did not disseminate significant epidemiologic information; deviated from its Risk Assessment Guidelines; failed to disclose important findings and reasoning..."

In 2002, the EPA successfully appealed this decision to the United States Court of Appeals for the Fourth Circuit. The EPA's appeal was upheld on the preliminary grounds that their report had no regulatory weight, and the earlier finding was vacated.

In 1998, the U.S. Department of Health and Human Services, through the publication by its National Toxicology Program of the 9th Report on Carcinogens, listed environmental tobacco smoke among the known carcinogens, observing of the EPA assessment that "The individual studies were carefully summarized and evaluated."

Tobacco-industry funding of research

The tobacco industry's role in funding scientific research on secondhand smoke has been controversial. A review of published studies found that tobacco-industry affiliation was strongly correlated with findings exonerating secondhand smoke; researchers affiliated with the tobacco industry were 88 times more likely than independent researchers to conclude that secondhand smoke was not harmful. In a specific example which came to light with the release of tobacco-industry documents, Philip Morris executives successfully encouraged an author to revise his industry-funded review article to downplay the role of secondhand smoke in sudden infant death syndrome. The 2006 U.S. Surgeon General's report criticized the tobacco industry's role in the scientific debate:

The industry has funded or carried out research that has been judged to be biased, supported scientists to generate letters to editors that criticized research publications, attempted to undermine the findings of key studies, assisted in establishing a scientific society with a journal, and attempted to sustain controversy even as the scientific community reached consensus.

This strategy was outlined at an international meeting of tobacco companies in 1988, at which Philip Morris proposed to set up a team of scientists, organized by company lawyers, to "carry out work on ETS to keep the controversy alive." All scientific research was subject to oversight and "filtering" by tobacco-industry lawyers:

Philip Morris then expect the group of scientists to operate within the confines of decisions taken by PM scientists to determine the general direction of research, which apparently would then be 'filtered' by lawyers to eliminate areas of sensitivity.

Philip Morris reported that it was putting "...vast amounts of funding into these projects... in attempting to coordinate and pay so many scientists on an international basis to keep the ETS controversy alive."

Tobacco industry response

Measures to tackle secondhand smoke pose a serious economic threat to the tobacco industry, having broadened the definition of smoking beyond a personal habit to something with a social impact. In a confidential 1978 report, the tobacco industry described increasing public concerns about secondhand smoke as "the most dangerous development to the viability of the tobacco industry that has yet occurred." In United States of America v. Philip Morris et al., the District Court for the District of Columbia found that the tobacco industry "... recognized from the mid-1970s forward that the health effects of passive smoking posed a profound threat to industry viability and cigarette profits," and that the industry responded with "efforts to undermine and discredit the scientific consensus that ETS causes disease."

Accordingly, the tobacco industry have developed several strategies to minimise the impact on their business:

• The industry has sought to position the secondhand smoke debate as essentially concerned with civil liberties and smokers' rights rather than with health, by funding groups such as FOREST.
• Funding bias in research; in all reviews of the effects of secondhand smoke on health published between 1980 and 1995, the only factor associated with concluding that secondhand smoke is not harmful was whether an author was affiliated with the tobacco industry. However, not all studies that failed to find evidence of harm were by industry-affiliated authors.
• Delaying and discrediting legitimate research (see for an example of how the industry attempted to discredit Takeshi Hirayama's landmark study, and for an example of how it attempted to delay and discredit a major Australian report on passive smoking)
• Promoting "good epidemiology" and attacking so-called junk science (a term popularised by industry lobbyist Steven Milloy): attacking the methodology behind research showing health risks as flawed and attempting to promote sound science. Ong & Glantz (2001) cite an internal Phillip Morris memo giving evidence of this as company policy.
• Creation of outlets for favourable research. In 1989, the tobacco industry established the International Society of the Built Environment, which published the peer-reviewed journal Indoor and Built Environment. This journal did not require conflict-of-interest disclosures from its authors. With documents made available through the Master Settlement, it was found that the executive board of the society and the editorial board of the journal were dominated by paid tobacco-industry consultants. The journal published a large amount of material on passive smoking, much of which was "industry-positive".

Citing the tobacco industry's production of biased research and efforts to undermine scientific findings, the 2006 U.S. Surgeon General's report concluded that the industry had "attempted to sustain controversy even as the scientific community reached consensus... industry documents indicate that the tobacco industry has engaged in widespread activities... that have gone beyond the bounds of accepted scientific practice." The U.S. District Court, in U.S.A. v. Philip Morris et al., found that "...despite their internal acknowledgment of the hazards of secondhand smoke, Defendants have fraudulently denied that ETS causes disease."

Position of major tobacco companies

The positions of major tobacco companies on the issue of secondhand smoke is somewhat varied. In general, tobacco companies have continued to focus on questioning the methodology of studies showing that secondhand smoke is harmful. Some (such as British American Tobacco and Philip Morris) acknowledge the medical consensus that secondhand smoke carries health risks, while others continue to assert that the evidence is inconclusive. Several tobacco companies advocate the creation of smoke-free areas within public buildings as an alternative to comprehensive smoke-free laws.

US racketeering lawsuit against tobacco companies

On September 22, 1999, the U.S. Department of Justice filed a racketeering lawsuit against Philip Morris and other major cigarette manufacturers. Almost 7 years later, on August 17, 2006, U.S. District Court Judge Gladys Kessler found that the Government had proven its case and that the tobacco company defendants had violated the Racketeer Influenced Corrupt Organizations Act (RICO). In particular, Judge Kessler found that PM and other tobacco companies had:

• conspired to minimize, distort and confuse the public about the health hazards of smoking;
• publicly denied, while internally acknowledging, that secondhand tobacco smoke is harmful to nonsmokers, and
• destroyed documents relevant to litigation.

The ruling found that tobacco companies undertook joint efforts to undermine and discredit the scientific consensus that secondhand smoke causes disease, notably by controlling research findings via paid consultants. The ruling also concluded that tobacco companies were fraudulently continuing to deny the health effects of ETS exposure.

On May 22, 2009, a three-judge panel of the U.S. Court of Appeals for the District of Columbia Circuit unanimously upheld the lower court's 2006 ruling.

Smoke-free laws

See also: Smoking ban, List of smoking bans, and Smoking bans in private vehicles

As a consequence of the health risks associated with secondhand smoke, many national and local governments have outlawed smoking in indoor public places, including restaurants, cafés, and nightclubs, as well as some outdoor open areas. Ireland was the first country in the world to institute a comprehensive national ban on smoking in all indoor workplaces on 29 March 2004. Since then, many others have followed suit. The countries which have ratified the WHO Framework Convention on Tobacco Control (FCTC) have a legal obligation to implement effective legislation "for protection from exposure to tobacco smoke in indoor workplaces, public transport, indoor public places and, as appropriate, other public places." (Article 8 of the FCTC) The parties to the FCTC have further adopted Guidelines on the Protection from Exposure to secondhand Smoke which state that "effective measures to provide protection from exposure to tobacco smoke ... require the total elimination of smoking and tobacco smoke in a particular space or environment in order to create a 100% smoke-free environment."

Opinion polls have shown considerable support for smoke-free laws. In June 2007, a survey of 15 countries found 80% approval for such laws. A survey in France, reputedly a nation of smokers, showed 70% support.

Effects

Smoking bans by governments result in decreased harm from secondhand smoke, including less admissions for acute coronary syndrome. In the first 18 months after the town of Pueblo, Colorado, enacted a smoke-free law in 2003, hospital admissions for heart attacks dropped 27%. Admissions in neighbouring towns without smoke-free laws showed no change, and the decline in heart attacks in Pueblo was attributed to the resulting reduction in secondhand smoke exposure. A 2004 smoking ban instituted in Massachusetts workplaces decreased workers' secondhand smoke exposure from 8% of workers in 2003 to 5.4% of workers in 2010. A 2016 review also found that bans and policy changes in specific locations such as hospitals or universities can lead to reduced smoking rates. In prison settings bans might lead to reduced mortality and to lower exposure to secondhand smoke.

In 2001, a systematic review for the Guide to Community Preventive Services acknowledged strong evidence of the effectiveness of smoke-free policies and restrictions in reducing expose to secondhand smoke. A follow-up to this review, identified the evidence on which the effectiveness of smoking bans reduced the prevalence of tobacco use. Articles published until 2005, were examined to further support this evidence. The examined studies provided sufficient evidence that smoke-free policies reduce tobacco use among workers when implemented in worksites or by communities.

While a number of studies funded by the tobacco industry have claimed a negative economic impact from smoke-free laws, no independently funded research has shown any such impact. A 2003 review reported that independently funded, methodologically sound research consistently found either no economic impact or a positive impact from smoke-free laws.

Air nicotine levels were measured in Guatemalan bars and restaurants before and after an implemented smoke-free law in 2009. Nicotine concentrations significantly decreased in both the bars and restaurants measured. Also, the employees' support for a smoke-free workplace substantially increased in the post-implementation survey compared to pre-implementation survey.

Public opinion

Recent surveys taken by the Society for Research on Nicotine and Tobacco demonstrate supportive attitudes of the public, towards smoke-free policies in outdoor areas. A vast majority of the public supports restricting smoking in various outdoor settings. The respondents' support for the policies were for varying reasons such as litter control, establishing positive smoke-free role models for youth, reducing youth opportunities to smoke, and avoiding exposure to secondhand smoke.

Alternative forms

Альтернативы законам о запрете курения также предлагались как средство снижения вреда , особенно в барах и ресторанах. Например, критики законов о запрете табачного дыма цитируют исследования, в которых предлагается, чтобы вентиляция была средством снижения содержания загрязняющих веществ табачного дыма и улучшения качества воздуха. Табачная промышленность также активно пропагандирует вентиляцию как альтернативу прямым запретам через сеть якобы независимых экспертов, часто не раскрывающих связей с табачной промышленностью. Однако не все критики связаны с индустрией.

Американское общество инженеров по отоплению, охлаждению и кондиционированию воздуха (ASHRAE) в 2005 году официально пришло к выводу, что, хотя полностью изолированные курительные комнаты действительно устраняют риск для близлежащих зон для некурящих, запрет на курение является единственным средством устранения рисков для здоровья, связанных с воздействием в помещении. . Они также пришли к выводу, что никакая система разбавления или очистки не эффективна для устранения риска. Главный хирург США и Объединенный исследовательский центр Европейской комиссии пришли к аналогичным выводам. В руководящих принципах реализации Рамочной конвенции ВОЗ по борьбе против табака говорится, что инженерные подходы, такие как вентиляция, неэффективны и не защищают от пассивного курения. Однако это не обязательно означает, что такие меры бесполезны для снижения вреда, а лишь то, что они не достигают цели полного снижения воздействия до нуля.

Другие предложили систему продаваемых разрешений на загрязнение от курения, аналогичную системе разрешений на выбросы квотами и торговлей, используемой Агентством по охране окружающей среды США в последние десятилетия для сдерживания других типов загрязнения. Это гарантировало бы, что часть баров/ресторанов в юрисдикции будет свободной от курения, оставив при этом решение на усмотрение рынка.

У животных

Основная статья: Животные и табачный дым

Было проведено множество исследований для определения канцерогенности табачного дыма из окружающей среды для животных. Эти исследования обычно подпадают под категории моделирования табачного дыма в окружающей среде, введения конденсатов побочного дыма или наблюдательных исследований рака среди домашних животных.

Чтобы имитировать табачный дым в окружающей среде, ученые подвергают животных воздействию побочного дыма, который исходит от горящего конуса сигареты и через ее бумагу, или комбинации основного и побочного дыма. В монографиях IARC делается вывод, что у мышей, подвергшихся длительному воздействию искусственного табачного дыма в окружающей среде, то есть по шесть часов в день, пять дней в неделю, в течение пяти месяцев с последующим четырехмесячным интервалом перед диссекцией, будет наблюдаться значительно более высокий уровень заболеваемости и множественности опухолей легких. чем в контрольных группах.

В монографиях IARC сделан вывод, что конденсаты побочного дыма оказывают значительно более сильное канцерогенное воздействие на мышей, чем конденсаты основного дыма.

Наблюдательные исследования

Пассивное курение широко признано фактором риска развития рака у домашних животных. Исследование, проведенное Школой ветеринарной медицины Университета Тафтса и Массачусетским университетом в Амхерсте, связало возникновение рака полости рта у кошек с воздействием табачного дыма в окружающей среде через сверхэкспрессию гена p53 . Другое исследование, проведенное в тех же университетах, пришло к выводу, что кошки, живущие с курильщиком, с большей вероятностью заболеют кошачьей лимфомой ; риск увеличивался с увеличением продолжительности воздействия пассивного курения и количества курильщиков в семье. Исследование, проведенное учеными из Университета штата Колорадо , посвященное случаям рака легких у собак, в целом оказалось безрезультатным, хотя авторы сообщили о слабой связи с раком легких у собак, подвергшихся воздействию табачного дыма в окружающей среде. Количество курильщиков в доме, количество пачек, выкуриваемых дома в день, и количество времени, которое собака проводила дома, не влияли на риск заболевания раком легких у собаки.

См. также

• Влияние табака на здоровье
• Пассивное курение
• Борьба против табака
• Филип Моррис против. Уругвай

Внешние ссылки

Научные организации

• Влияние на здоровье воздействия табачного дыма в окружающей среде , данные Национального института рака США.
• «Экологический табачный дым» (PDF) . Архивировано (PDF) из оригинала 16 июля 2008 г.   (219 КБ) . Из 11-го доклада о канцерогенах Национального института здравоохранения США.
• Министерство здравоохранения и социальных служб США; Центры по контролю и профилактике заболеваний; Координационный центр укрепления здоровья; Национальный центр профилактики хронических заболеваний и укрепления здоровья; Управление по курению и здоровью (27 июня 2006 г.). «Последствия для здоровья непроизвольного воздействия табачного дыма: отчет главного хирурга» . Публикации и отчеты главного хирурга. Атланта, Джорджия: Главный хирург США . ПМИД   20669524 . O2NLM: WA 754 H4325 2006. Пассивное курение вызывает заболевания и преждевременную смерть у некурящих детей и взрослых. {{cite journal}}: Для цитирования журнала требуется |journal= ( помощь )
• Всемирная организация здравоохранения ; Международное агентство по исследованию рака (2004 г.). Табачный дым и принудительное курение (PDF) . Монографии МАИР по оценке канцерогенного риска для человека. Том. 83. Лион, Франция: Рабочая группа МАИР по оценке канцерогенных рисков для человека. ISBN  978-92-832-1283-6 .
• Информационный бюллетень о пассивном курении от Центров США по контролю и профилактике заболеваний
• Табачный дым на рабочем месте : Центры США по контролю и профилактике заболеваний
• Влияние на здоровье воздействия табачного дыма в окружающей среде , от Калифорнийского агентства по охране окружающей среды.
• Воздействие табачного дыма на окружающую среду среди детей в возрасте 3–19 лет с астмой и без нее в США, 1999–2010 гг. Национальный центр статистики здравоохранения
• Оберг, Маттиас; Яаккола, Маритта С; Вудворд, Алистер; Перуга, Армандо; Прюсс-Устюн, Аннет (январь 2011 г.). «Мировое бремя болезней от воздействия вторичного табачного дыма: ретроспективный анализ данных из 192 стран». Ланцет . 377 (9760): 139–146. дои : 10.1016/S0140-6736(10)61388-8 . ПМИД   21112082 . S2CID   7179156 .

Табачная промышленность

• «Стратегии табачных компаний, направленные на подрыв деятельности по борьбе против табака» (PDF) . Архивировано из оригинала (PDF) 21 августа 2004 г. Проверено 5 октября 2020 г.   (1,55 МБ) : Отчет Комитета экспертов по табачной промышленности. Документы Всемирной организации здравоохранения.
• Библиотека документов Legacy Tobacco и Архив документов British American Tobacco . Калифорнийского университета в Сан-Франциско
• Архив документов Philip Morris USA , обнародованный в результате Генерального соглашения по урегулированию споров в отношении табачных изделий.

Другие ссылки

• Рекомендации по защите от пассивного курения , Рамочная конвенция ВОЗ по борьбе против табака
• Политические рекомендации ВОЗ по защите от воздействия вторичного табачного дыма
• Маленькая, Элизия; Шах, Хина П.; Давенпорт, Джейк Дж.; Гейер, Жаклин Э.; Яварович, Катя Р.; Ямада, Хидетака; Сабаринатх, Шридхаран Н.; Дерендорф, Хартмут; Поли, Джеймс Р.; Голд, Марк С.; Брейнзель, Адри В. (январь 2010 г.). «Воздействие табачного дыма вызывает никотиновую зависимость у крыс» . Психофармакология . 208 (1): 143–158. дои : 10.1007/s00213-009-1716-z . ПМК   3586198 . ПМИД   19936715 .
• Кесслер, Глэдис (17 августа 2006 г.). «Соединенные Штаты Америки против Филип Моррис и др.: Окончательное мнение судьи Глэдис Кесслер» (PDF) . Окружной суд США по округу Колумбия .
• «Как пассивное курение меняет ваши гены»