TEK Тирозинкиназа

ТОЛЬКО
Доступные структуры
PDB	Поиск ортолога: PDBE RCSB
showСписок кодов идентификаторов PDB
	4K0V, 1FVR, 2GY5, 2GY7, 2OO8, 2OSC, 2P4I, 2WQB, 3L8P, 4X3J
Идентификаторы
Псевдонимы	TEK , CD202B, TIE-2, TIE2, VMCM, VMCM1, TEK Тирозинкиназа, рецептор TEK Тирозинкиназа, GLC3E
Внешние идентификаторы	Омим : 600221 ; MGI : 98664 ; Гомолоэген : 397 ; GeneCards : Tek ; OMA : Tek - ортологи
showМестоположение гена ( человек )
Chr.	Chromosome 9 (human)
End	27,230,174 bp
showGene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	94,763,213 bp
showRNA expression pattern
	Top expressed in
	right lung; ; visceral pleura; ; upper lobe of left lung; ; oocyte; ; parietal pleura; ; secondary oocyte; ; lower lobe of lung; ; subcutaneous adipose tissue; ; metanephric glomerulus; ; placenta;
	Top expressed in
	Vasculature of brain; ; right lung; ; right lung lobe; ; left lung; ; atrium; ; left lung lobe; ; atrioventricular valve; ; semi-lunar valve; ; aortic valve; ; endocardial cushion;
	More reference expression data
	; ;
	More reference expression data
showGene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; kinase activity; protein binding; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; ATP binding; signaling receptor activity; growth factor binding; receptor tyrosine kinase; transmembrane signaling receptor activity;
Cellular component	cytoplasm; integral component of membrane; membrane; cell-cell junction; focal adhesion; integral component of plasma membrane; stress fiber; extracellular region; microvillus; cell surface; basal plasma membrane; cell junction; basolateral plasma membrane; apical plasma membrane; actin filament; membrane raft; cytoskeleton; microtubule organizing center; plasma membrane; receptor complex;
Biological process	negative regulation of endothelial cell apoptotic process; positive regulation of protein kinase B signaling; positive regulation of protein phosphorylation; response to hypoxia; positive regulation of endothelial cell proliferation; heart trabecula formation; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of endothelial cell apoptotic process; cell-cell signaling; response to peptide hormone; sprouting angiogenesis; negative regulation of apoptotic process; endochondral ossification; positive regulation of intracellular signal transduction; response to organic substance; positive regulation of angiogenesis; MAPK cascade; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of endothelial cell migration; response to estrogen; heart development; regulation of vascular permeability; protein phosphorylation; protein complex oligomerization; endothelial cell proliferation; angiogenesis; Tie signaling pathway; positive regulation of ERK1 and ERK2 cascade; negative regulation of angiogenesis; protein autophosphorylation; positive regulation of focal adhesion assembly; regulation of establishment or maintenance of cell polarity; positive regulation of phosphatidylinositol 3-kinase signaling; peptidyl-tyrosine phosphorylation; substrate adhesion-dependent cell spreading; response to cAMP; definitive hemopoiesis; positive regulation of actin cytoskeleton reorganization; negative regulation of inflammatory response; leukocyte migration; signal transduction; glomerulus vasculature development; negative regulation of signal transduction; cell differentiation;
	Sources:Amigo / QuickGO
hideOrthologs
	7010
	21687
	ENSG00000120156
	ENSMUSG00000006386
	Q02763
	Q02858
	NM_000459; NM_001290077; NM_001290078; NM_001375475; NM_001375476
	NM_001290549; NM_001290551; NM_013690
	NP_000450; NP_001277006; NP_001277007; NP_001362404; NP_001362405
	NP_001277478; NP_001277480; NP_038718
	Wikidata
View/Edit Human	View/Edit Mouse

Рецептор ангиопоэтина-1, также известный как CD202B ( кластер дифференцировки 202B), является белком , который у людей кодируется TEK геном . ^{[ 5 ]}^{[ 6 ]} Также известный как Tie2 , это рецептор ангиопоэтина .

Функция

Тирозинкиназа рецептора TEK экспрессируется почти исключительно в эндотелиальных клетках у мышей, крыс и людей. (TEK тесно связан с рецепторной тирозинкиназой .) ^{[ 7 ]}

Этот рецептор обладает уникальным внеклеточным доменом, содержащим 2 иммуноглобулиноподобных петли, разделенных 3 эпидермальными репрессиями, подобными факторам роста, которые связаны с 3-подобными типами фибронектина типа III. ^{[ 8 ]} Лигандом для рецептора является ангиопоэтин-1. ^{[ 7 ]} TEK также был предложен в качестве маркера для клеток-предшественников Pulposus ядра , из межпозвоночного диска , который после активации ангиопоэтином-1 начинает размножаться и дифференцироваться. ^[9]^[10]

Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis.^[7]

In cancer patients, TEK (Tie2) is expressed in a subpopulation of monocytes that home in on the tumor and are essential for the formation of new blood vessels there.^[11]

Interactions

TEK tyrosine kinase has been shown to interact with:

References

^ Jump up to: ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000120156 – Ensembl, May 2017
^ Jump up to: ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006386 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Partanen J, Armstrong E, Mäkelä TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K (April 1992). "A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains". Molecular and Cellular Biology. 12 (4): 1698–707. doi:10.1128/mcb.12.4.1698. PMC 369613. PMID 1312667.
^ Boon LM, Mulliken JB, Vikkula M, Watkins H, Seidman J, Olsen BR, Warman ML (September 1994). "Assignment of a locus for dominantly inherited venous malformations to chromosome 9p". Human Molecular Genetics. 3 (9): 1583–7. doi:10.1093/hmg/3.9.1583. PMID 7833915.
^ Jump up to: ^a ^b ^c "Entrez Gene: TEK TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)".
^ Jump up to: ^a ^b ^c Fiedler U, Krissl T, Koidl S, Weiss C, Koblizek T, Deutsch U, et al. (January 2003). "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats". The Journal of Biological Chemistry. 278 (3): 1721–7. doi:10.1074/jbc.M208550200. PMID 12427764.
^ Sakai D, Nakamura Y, Nakai T, Mishima T, Kato S, Grad S, et al. (2012). "Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc". Nature Communications. 3: 1264. Bibcode:2012NatCo...3.1264S. doi:10.1038/ncomms2226. PMC 3535337. PMID 23232394.
^ Sakai D, Schol J, Bach FC, Tekari A, Sagawa N, Nakamura Y, et al. (June 2018). "Successful fishing for nucleus pulposus progenitor cells of the intervertebral disc across species". JOR Spine. 1 (2): e1018. doi:10.1002/jsp2.1018. PMC 6686801. PMID 31463445.
^ Venneri MA, De Palma M, Ponzoni M, Pucci F, Scielzo C, Zonari E, et al. (June 2007). "Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer". Blood. 109 (12): 5276–85. doi:10.1182/blood-2006-10-053504. PMID 17327411. S2CID 13999825.
^ Jump up to: ^a ^b Sato A, Iwama A, Takakura N, Nishio H, Yancopoulos GD, Suda T (August 1998). "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells". International Immunology. 10 (8): 1217–27. doi:10.1093/intimm/10.8.1217. PMID 9723709.
^ Jump up to: ^a ^b Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD (July 1997). "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science. 277 (5322): 55–60. doi:10.1126/science.277.5322.55. PMID 9204896.
^ Davis S, Aldrich TH, Jones PF, Acheson A, Compton DL, Jain V, Ryan TE, Bruno J, Radziejewski C, Maisonpierre PC, Yancopoulos GD (December 1996). "Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning". Cell. 87 (7): 1161–9. doi:10.1016/s0092-8674(00)81812-7. PMID 8980223.
^ Jones N, Dumont DJ (September 1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R". Oncogene. 17 (9): 1097–108. doi:10.1038/sj.onc.1202115. PMID 9764820. S2CID 20187169.
^ Master Z, Jones N, Tran J, Jones J, Kerbel RS, Dumont DJ (November 2001). "Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak". The EMBO Journal. 20 (21): 5919–28. doi:10.1093/emboj/20.21.5919. PMC 125712. PMID 11689432.

Внешние ссылки

GeneReviews/ncbi/nih/uw intry на множественных кожных и слизистых венозных пороках.
Обзор всей структурной информации, доступной в PDB для Uniprot : Q02763 (рецептор ангиопоэтин-1) в PDBE-KB .

Эта статья включает в себя текст из Национальной медицины Соединенных Штатов , которая находится в общественном достоянии .

[refGRCh38Ensembl-1] Jump up to: ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000120156 – Ensembl, May 2017

[refGRCm38Ensembl-2] Jump up to: ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006386 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1312667-5] Partanen J, Armstrong E, Mäkelä TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K (April 1992). "A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains". Molecular and Cellular Biology. 12 (4): 1698–707. doi:10.1128/mcb.12.4.1698. PMC 369613. PMID 1312667.

[pmid7833915-6] Boon LM, Mulliken JB, Vikkula M, Watkins H, Seidman J, Olsen BR, Warman ML (September 1994). "Assignment of a locus for dominantly inherited venous malformations to chromosome 9p". Human Molecular Genetics. 3 (9): 1583–7. doi:10.1093/hmg/3.9.1583. PMID 7833915.

[TEK-7] Jump up to: ^a ^b ^c "Entrez Gene: TEK TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)".

[Fiedler_2003-8] Jump up to: ^a ^b ^c Fiedler U, Krissl T, Koidl S, Weiss C, Koblizek T, Deutsch U, et al. (January 2003). "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats". The Journal of Biological Chemistry. 278 (3): 1721–7. doi:10.1074/jbc.M208550200. PMID 12427764.

[9] Sakai D, Nakamura Y, Nakai T, Mishima T, Kato S, Grad S, et al. (2012). "Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc". Nature Communications. 3: 1264. Bibcode:2012NatCo...3.1264S. doi:10.1038/ncomms2226. PMC 3535337. PMID 23232394.

[10] Sakai D, Schol J, Bach FC, Tekari A, Sagawa N, Nakamura Y, et al. (June 2018). "Successful fishing for nucleus pulposus progenitor cells of the intervertebral disc across species". JOR Spine. 1 (2): e1018. doi:10.1002/jsp2.1018. PMC 6686801. PMID 31463445.

[11] Venneri MA, De Palma M, Ponzoni M, Pucci F, Scielzo C, Zonari E, et al. (June 2007). "Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer". Blood. 109 (12): 5276–85. doi:10.1182/blood-2006-10-053504. PMID 17327411. S2CID 13999825.

[pmid9723709-12] Jump up to: ^a ^b Sato A, Iwama A, Takakura N, Nishio H, Yancopoulos GD, Suda T (August 1998). "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells". International Immunology. 10 (8): 1217–27. doi:10.1093/intimm/10.8.1217. PMID 9723709.

[pmid9204896-13] Jump up to: ^a ^b Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD (July 1997). "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science. 277 (5322): 55–60. doi:10.1126/science.277.5322.55. PMID 9204896.

[pmid8980223-14] Davis S, Aldrich TH, Jones PF, Acheson A, Compton DL, Jain V, Ryan TE, Bruno J, Radziejewski C, Maisonpierre PC, Yancopoulos GD (December 1996). "Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning". Cell. 87 (7): 1161–9. doi:10.1016/s0092-8674(00)81812-7. PMID 8980223.

[pmid9764820-15] Jones N, Dumont DJ (September 1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R". Oncogene. 17 (9): 1097–108. doi:10.1038/sj.onc.1202115. PMID 9764820. S2CID 20187169.

[pmid11689432-16] Master Z, Jones N, Tran J, Jones J, Kerbel RS, Dumont DJ (November 2001). "Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak". The EMBO Journal. 20 (21): 5919–28. doi:10.1093/emboj/20.21.5919. PMC 125712. PMID 11689432.

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v Т и Белки : кластеры дифференцировки (см. Также список человеческих кластеров дифференцировки )
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

v Т и Ферменты
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

TEK Тирозинкиназа

Функция

Interactions

See also

References

Further reading

Внешние ссылки