List of dopaminergic drugs

This is a list of dopaminergic drugs. These are pharmaceutical drugs, naturally occurring compounds and other chemicals that influence the function of the neurotransmitter dopamine.

Receptor ligands

Agonists

Adamantanes: Amantadine •Memantine •Rimantadine

Aminotetralins: 7-OH-DPAT •8-OH-PBZI •Rotigotine •UH-232

Benzazepines: 6-Br-APB •Fenoldopam •SKF-38,393 •SKF-77,434 •SKF-81,297 •SKF-82,958 •SKF-83,959

Ergolines: Bromocriptine •Cabergoline •Dihydroergocryptine •Lisuride •Lysergic acid diethylamide (LSD) •Pergolide

Dihydrexidine derivatives: 2-OH-NPA •A-86,929 •Ciladopa •Dihydrexidine •Dinapsoline •Dinoxyline •Doxanthrine

Others: A-68,930 •A-77,636 •A-412,997 •ABT-670 •ABT-724 •Aplindore •Apomorphine •Aripiprazole •Azodopa •Bifeprunox •BP-897 •CY-208,243 •Dizocilpine •Etilevodopa •Flibanserin •Ketamine •Melevodopa •Modafinil •Pardoprunox •Phencyclidine •PD-128,907 •PD-168,077 •PF-219,061 •Piribedil •Pramipexole •Propylnorapomorphine •Pukateine •Quinagolide •Quinelorane •Quinpirole •RDS-127 •Ro10-5824 •Ropinirole •Rotigotine •Roxindole •Salvinorin A •SKF-89,145 •Sumanirole •Terguride •Umespirone •WAY-100,635

Antagonists

Typical antipsychotics: Acepromazine •Azaperone •Benperidol •Bromperidol •Clopenthixol •Chlorpromazine •Chlorprothixene •Droperidol •Flupentixol •Fluphenazine •Fluspirilene •Haloperidol •Loxapine •Mesoridazine •Methotrimeprazine •Nemonapride •Penfluridol •Perazine •Periciazine •Perphenazine •Pimozide •Prochlorperazine •Promazine •Sulforidazine •Sulpiride •Sultopride •Thioridazine •Thiothixene •Trifluoperazine •Triflupromazine •Trifluperidol •Zuclopenthixol

Atypical antipsychotics: Amisulpride •Asenapine •Blonanserin •Cariprazine •Carpipramine •Clocapramine •Clozapine •Gevotroline •Iloperidone •Lurasidone •Melperone •Molindone •Mosapramine •Ocaperidone •Olanzapine •Paliperidone •Perospirone •Piquindone •Quetiapine •Remoxipride •Risperidone •Sertindole •Tiospirone •Ziprasidone •Zotepine

Antiemetics: AS-8112 •Alizapride •Bromopride •Clebopride •Domperidone •Metoclopramide •Thiethylperazine

Others: Amoxapine •Buspirone •Butaclamol •Ecopipam •N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) •Eticlopride •Fananserin •L-745,870 •Nafadotride •Nuciferine •PNU-99,194 •Raclopride •Sarizotan •SB-277,011-A •SCH-23,390 •SKF-83,566 •SKF-83,959 •Sonepiprazole •Spiperone •Spiroxatrine •Stepholidine •Tetrahydropalmatine •Tiapride •UH-232 •Yohimbine

Reuptake inhibitors

Dopamine transporter (DAT) inhibitors

Piperazines: DBL-583 •GBR-12,935 •Nefazodone •Vanoxerine

Piperidines: 1-(1-(1-Benzothiophen-2-yl)cyclohexyl)piperidine (BTCP) •Desoxypipradrol •Dextromethylphenidate •Difemetorex •Ethylphenidate •Methylnaphthidate •Isopropylphenidate •Methylphenidate •Phencyclidine •Pipradrol

Pyrrolidines: Diphenylprolinol •Methylenedioxypyrovalerone (MDPV) •Naphyrone •Prolintane •Pyrovalerone

Tropanes: 3β-(4'-Chlorophenyl)-2β-(3'-phenylisoxazol-5'-yl)tropane (β-CPPIT) •Altropane •Brasofensine •WIN 35428 (β-CFT) •Cocaine •Dichloropane •Difluoropine •N-(2'-Fluoroethyl-)-3β-(4'-chlorophenyl)-2β-(3'-phenylisoxazol-5'-yl)nortropane (FE-β-CPPIT) •N-(3'-Fluoropropyl-)-3β-(4'-chlorophenyl)-2β-(3'-phenylisoxazol-5'-yl)nortropane (FP-β-CPPIT) •Ioflupane (¹²³I) •Iometopane •RTI-112 •RTI-113 •RTI-121 •RTI-126 •RTI-150 •RTI-177 •RTI-229 •RTI-336 •Tenocyclidine •Tesofensine •Troparil •Tropoxane •2β-Propanoyl-3β-(4-tolyl)-tropane (WF-11) •2β-Propanoyl-3β-(2-naphthyl)-tropane (WF-23) •2-Propanoyl-3-(4-isopropylphenyl)-tropane (WF-31) •2α-(Propanoyl)-3β-(2-(6-methoxynaphthyl))-tropane (WF-33)

Others: Adrafinil •Armodafinil •Amfonelic acid •Amineptine •Benzatropine (benztropine) •Bromantane •2-Butyl-3-(p-tolyl)quinuclidine (BTQ) •BTS-74,398 •Bupropion (amfebutamone) •Ciclazindol •Diclofensine •Dimethocaine •Diphenylpyraline •Dizocilpine •DOV-102,677 •DOV-21,947 •DOV-216,303 •Etybenzatropine (ethylbenztropine) •EXP-561 •Fencamine •Fencamfamine •Fezolamine •GYKI-52,895 •Hydrafinil •Indatraline •Ketamine •Lefetamine •Levophacetoperane •LR-5182 •Manifaxine •Mazindol •Medifoxamine •Mesocarb •Modafinil •Nefopam •Nomifensine •NS-2359 •O-2172 •Pridefrine •Propylamphetamine •Radafaxine •SEP-225,289 •SEP-227,162 •Sertraline •Sibutramine •Tametraline •Tripelennamine

Vesicular monoamine transporter (VMAT) inhibitors

Deserpidine •Ibogaine •Reserpine •Tetrabenazine

Releasing agents

Morpholines: Fenbutrazate •Morazone •Phendimetrazine •Phenmetrazine

Oxazolines: 4-Methylaminorex (4-MAR, 4-MAX) •Aminorex •Clominorex •Cyclazodone •Fenozolone •Fluminorex •Pemoline •Thozalinone

Phenethylamines (also amphetamines, cathinones, phentermines, etc.): 2-Hydroxyphenethylamine (2-OH-PEA) •4-Chlorophenylisobutylamine (4-CAB) •4-Methylamphetamine (4-MA) •4-Methylmethamphetamine (4-MMA) •Alfetamine •Amfecloral •Amfepentorex •Amfepramone •Amphetamine (dextroamphetamine, levoamphetamine) •Amphetaminil •β-Methylphenethylamine (β-Me-PEA) •Benzodioxolylbutanamine (BDB) •Benzodioxolylhydroxybutanamine (BOH) •Benzphetamine •Buphedrone •Butylone •Cathine •Cathinone •Clobenzorex •Clortermine •D-Deprenyl •Dimethoxyamphetamine (DMA) •Dimethoxymethamphetamine (DMMA) •Dimethylamphetamine •Dimethylcathinone (dimethylpropion, metamfepramone) •Ethcathinone (ethylpropion) •Ethylamphetamine •Ethylbenzodioxolylbutanamine (EBDB) •Ethylone •Famprofazone •Fenethylline •Fenproporex •Flephedrone •Fludorex •Furfenorex •Hordenine •Lophophine (homomyristicylamine) •Mefenorex •Mephedrone •Methamphetamine (desoxyephedrine, methedrine; dextromethamphetamine, levomethamphetamine) •Methcathinone (methylpropion) •Methedrone •Methoxymethylenedioxyamphetamine (MMDA) •Methoxymethylenedioxymethamphetamine (MMDMA) •Methylbenzodioxolylbutanamine (MBDB) •Methylenedioxyamphetamine (MDA, tenamfetamine) •Methylenedioxyethylamphetamine (MDEA) •Methylenedioxyhydroxyamphetamine (MDOH) •Methylenedioxymethamphetamine (MDMA) •Methylenedioxymethylphenethylamine (MDMPEA, homarylamine) •Methylenedioxyphenethylamine (MDPEA, homopiperonylamine) •Methylone •Ortetamine •Parabromoamphetamine (PBA) •Parachloroamphetamine (PCA) •Parafluoroamphetamine (PFA) •Parafluoromethamphetamine (PFMA) •Parahydroxyamphetamine (PHA) •Paraiodoamphetamine (PIA) •Paredrine (norpholedrine, oxamphetamine) •Phenethylamine (PEA) •Pholedrine •Phenpromethamine •Prenylamine •Propylamphetamine •Tiflorex (flutiorex) •Tyramine (TRA) •Xylopropamine •Zylofuramine

Piperazines: 2,5-Dimethoxy-4-bromobenzylpiperazine (2C-B-BZP) •Benzylpiperazine (BZP) •Methoxyphenylpiperazine (MeOPP, paraperazine) •Methylbenzylpiperazine (MBZP) •Methylenedioxybenzylpiperazine (MDBZP, piperonylpiperazine)

Others: 2-Amino-1,2-dihydronaphthalene (2-ADN) •2-Aminoindane (2-AI) •2-Aminotetralin (2-AT) •4-Benzylpiperidine (4-BP) •5-Iodo-2-aminoindane (5-IAI) •Clofenciclan •Cyclopentamine •Cypenamine •Cyprodenate •Feprosidnine •Gilutensin •Heptaminol •Hexacyclonate •Indanylaminopropane (IAP) •Indanorex •Isometheptene •Methylhexanamine •Naphthylaminopropane (NAP) •Octodrine •Phthalimidopropiophenone •Propylhexedrine (levopropylhexedrine) •Tuaminoheptane (tuamine)

Enzyme inhibitors

Synthesis inhibitors

Degradation inhibitors

Monoamine oxidase (MAO) inhibitors

Nonselective: Benmoxin •Caroxazone •Echinopsidine •Furazolidone •Hydralazine •Indantadol •Iproclozide •Iproniazid •Isocarboxazid •Isoniazid •Linezolid •Mebanazine •Metfendrazine •Nialamide •Octamoxin •Paraxazone •Phenelzine •Pheniprazine •Phenoxypropazine •Pivalylbenzhydrazine •Procarbazine •Safrazine •Tranylcypromine

MAO-A selective: Amiflamine •Bazinaprine •Befloxatone •Befol •Brofaromine •Cimoxatone •Clorgiline •Esuprone •Harmala alkaloids (harmine, harmaline, tetrahydroharmine, harman, norharman, etc.) •Methylene blue •Metralindole •Minaprine •Moclobemide •Pirlindole •Sercloremine •Tetrindole •Toloxatone •Tyrima

MAO-B selective: D-Deprenyl •Selegiline (L-deprenyl) •Ladostigil •Lazabemide •Milacemide •Mofegiline •Pargyline •Rasagiline •Safinamide

Catechol-O-methyl transferase (COMT) inhibitors

Entacapone •Nitecapone •Opicapone •Tolcapone

Dopamine beta hydroxylase inhibitors

Bupicomide •Disulfiram •Dopastin •Fusaric acid •Nepicastat •Phenopicolinic acid •Tropolone

Others

Precursors

L-Phenylalanine → L-tyrosine → L-DOPA (levodopa)

Cofactors

Ferrous iron (Fe²⁺) •Tetrahydrobiopterin •Vitamin B₃ (niacin, nicotinamide → NADPH) •Vitamin B₆ (pyridoxine, pyridoxamine, pyridoxal → pyridoxal phosphate) •Vitamin B₉ (folic acid → tetrahydrofolic acid) •Vitamin C (ascorbic acid) •Zinc (Zn²⁺)

Activity enhancers

Benzofuranylpropylaminopentane (BPAP) •Phenylpropylaminopentane (PPAP) •Selegiline (L-deprenyl)

Toxins

Oxidopamine (6-hydroxydopamine)

Levodopa prodrugs

XP21279

Photoswitchable ligands

A photoswitchable agonist of D₁-like receptors (azodopa) has been described that allows reversible control of dopaminergic transmission in wildtype animals.

References